While ago I did try version 2.98 (patched for 68060) which was tested with a lot of software 25 years ago using copyback cache, and probably the best version still released by Tony Tebby. The cache management extension from Mark Swift was required back then. If I remember correctly, there was no difference in behaviour of the two or three QLiberated programs I tried. SMSQ/E booted from RAM or ROM makes no difference.
More systematic investigation would indeed be nice, since we have already seen that primitive Qliberated programs do not immediately malfunction. 25 years ago, all this was not in my focus, because the software I used was not QLiberated. And after the license war, I stopped using SMSQ/E until it became free software. So there is little I can say about the history. Also I can not become QLiberator investigator today, that would distract me way too much.
I have to concentrate on hardware and low level software. To develop a new 68060 mainboard is an extreme effort, especially if a public release is the ultimate goal. I was bringing this to attention in the hope that someone software oriented would care enough to look into gaining 68040/68060 compatibility.
As already mentioned, this does not necessarily require QLib compilation, since it brings no speed improvement. If another form of software deployment acceptable for QLib users can be achieved with a new tool, that's also fine. My gut feeling says the latter has a higher chance to succeed, but that might also be totally wrong.